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Dr. David Graham, an FDA scientist and whistleblower, said he was firmly discouraged from publishing his data questioning the safety of Vioxx, which was recalled last September.
The paper suggested while Vioxx was on the market from 1999 to September 2004, it caused up to 140,000 serious injuries or deaths. A leading international medical journal, The Lancet, was supposed to publish Graham's paper on November 17, but has just released it online.
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Analyst Richard Evans at Stanford C. Bernstein wrote in a research report that Merck's liability for the withdrawn arthritis painkiller Vioxx could reach $38 billion. This number is based off the assumption that 58,000 heart attacks could be linked to the drug, with an average settlement being $650,000.
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The Wall Street Journal has reported internal emails and other documents from Merck & Co. show the drug company may have fought for years to keep Vioxx safety concerns from injuring the high generating sales of the drug instead of from patients. Vioxx was withdrawn after evidence the popular drug caused double the risk of heart attack and stroke in patients who had been taking it for at least 18 months was shown. Merck claims it immediately acted when discovering adverse effects were linked to Vioxx, but evidence shows the company may have been avoiding signs for years.